Development Of A Noninvasive Blood Glucose Monitoring System Prototype: Pilot Study
조회 수 20 추천 수 0 2025.09.02 15:46:13일정시작 : | 0-00-00 (화) |
---|---|
일정종료 : | 59-00-99 (목) |
Background: Diabetes mellitus is a severe illness characterized by high blood glucose ranges ensuing from dysregulation of the hormone insulin. Diabetes is managed via bodily activity and dietary modification and requires cautious monitoring of blood glucose concentration. Blood glucose concentration is usually monitored throughout the day by analyzing a pattern of blood drawn from a finger prick using a commercially obtainable glucometer. However, this process is invasive and painful, real-time SPO2 tracking and leads to a threat of infection. Therefore, there may be an urgent need for noninvasive, cheap, novel platforms for steady blood sugar monitoring. Objective: Our examine aimed to describe a pilot test to test the accuracy of a noninvasive glucose monitoring prototype that uses laser technology primarily based on near-infrared spectroscopy. Methods: Our system is based on Raspberry Pi, a portable camera (Raspberry Pi camera), and a visible gentle laser. The Raspberry Pi digicam captures a set of photos when a seen mild laser passes by means of pores and skin tissue. The glucose concentration is estimated by an artificial neural network mannequin using the absorption and scattering of gentle in the skin tissue.
This prototype was developed utilizing TensorFlow, Keras, and Python code. A pilot study was run with eight volunteers that used the prototype on their fingers and ears. Blood glucose values obtained by the prototype have been in contrast with commercially available glucometers to estimate accuracy. Results: When using photos from the finger, the accuracy of the prototype is 79%. Taken from the ear, the accuracy is attenuated to 62%. Though the present data set is limited, these results are encouraging. However, three main limitations have to be addressed in future research of the prototype: BloodVitals insights (1) improve the size of the database to enhance the robustness of the synthetic neural community model; (2) analyze the affect of exterior BloodVitals insights elements equivalent to skin shade, skin thickness, and ambient temperature in the present prototype; and (3) improve the prototype enclosure to make it appropriate for easy finger and BloodVitals home monitor ear placement. Conclusions: Our pilot research demonstrates that blood glucose concentration may be estimated using a small hardware prototype that makes use of infrared images of human tissue.
Although extra studies need to be conducted to beat limitations, this pilot examine shows that an affordable system can be used to keep away from the use of blood and multiple finger pricks for blood glucose monitoring in the diabetic inhabitants. Successful management of diabetes includes monitoring blood glucose levels a number of occasions per day. This device determines glucose concentration from a droplet of blood obtained from a finger prick or a laboratory blood draw. Therefore, noninvasive methods are a sexy alternative, however, those who are available as we speak have several limitations. Figure 1 illustrates an example of each type of noninvasive and minimally invasive blood glucose monitoring. These units have the benefit of being each portable and inexpensive. Here, we describe the development of a novel noninvasive glucose monitoring system that makes use of the computing energy of sensors and Internet of Things devices to constantly analyze blood glucose from a microcomputer and a sensor embedded within a clip positioned on the finger or ear. The prototype makes use of infrared spectroscopy to create pictures of the rotational and Blood Vitals vibrational transitions of chemical bonds inside the glucose molecule, and incident mild reflection to measure their corresponding fluctuation.
The photographs are converted into an array list, which is used to offer entries for an synthetic neural network (ANN) to create an estimate of blood glucose concentration. The prototype is straightforward to use and is paired with a mobile app without spending a dime-dwelling environments. Figure 2 shows an summary of the proposed system. I0 is the preliminary mild depth (W/cm2), I is the depth of the ith at any depth inside the absorption medium in W/cm2, l is the absorption depth throughout the medium in centimeters, e is the molar extinction coefficient in L/(mmol cm), and c is the concentration of absorbing molecules in mmol/L. The product of and c is proportional to the absorption coefficient (µa). The concentration of absorbing molecules is based on the above equation. However, the impact of other blood parts and absorbing tissue components affects the amount of light absorbed. Then, BloodVitals insights to attenuate the absorption attributable to all the other components, the wavelength of the sunshine source must be chosen so that the light source is extremely absorbed by glucose and is mostly clear to blood and tissue parts.
Although the Raspberry Pi digital camera captures pictures, a laser mild captures absorption. A small clip that may be positioned on a finger or earlobe holds the laser on the top half and the digicam on the bottom. Figure 3 depicts the elements of the prototype (Raspberry Pi, camera, and laser gentle). The prototype has been named GlucoCheck. The Raspberry Pi camera captures one image every 8 seconds over 2 minutes, for a complete of 15 images. Brightness and contrast ranges are set to 70 cycles/degree, digital camera ISO sensitivity is set to 800, and decision is ready to 640 × 480. Figures 4 and 5 present the prototype hooked up to the finger and ear, respectively. The supplies for the GlucoCheck prototype value roughly US $79-$154 in 2022, relying on the availability of chips, which has been an ongoing situation in recent months. Typically, pc boards are abundant, but 2022 noticed a scarcity of chips, resulting in inflated prices in comparison with earlier years.